Topical formulas applied right after SkinPen microneedling or laser, when skin is most receptive, and added only when our providers decide they fit your plan.
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See Your PotentialBoth are topical formulas applied to freshly treated skin. They do different jobs, so we choose between them rather than adding both by default.
| Peptides | Exosomes | |
|---|---|---|
| What it is | Short chains of amino acids, the building blocks of proteins such as collagen and elastin. | Tiny vesicles that cells release to communicate with one another. |
| What it supports | Firmness, smoothness and overall skin quality. | Recovery and renewal after microneedling or laser. |
| How we use it | Applied after your paired treatment, and available for home care in our Rejuv Facial Firming Peptides serum. | Applied in the office to treated skin while it is most receptive. |
| The evidence | Works alongside your treatment series and daily routine, not on its own. | Research is still developing, and results vary from person to person. |
Peptides and exosomes are add-ons, not standalone treatments. They go on immediately after a treatment that opens or refreshes the skin.
SkinPen creates micro-channels that stimulate collagen and let topical formulas reach deeper layers of the skin. A session usually takes 30 to 60 minutes.
After laser resurfacing such as Aerolase, a supportive topical can be part of your post-laser care.
Growth factors from your own blood can also be applied during microneedling or laser, and your provider explains how that compares with an exosome formula.
Peptide and exosome treatments may suit healthy adults who are already planning a skin-renewing treatment and want added support.
Formulas can be applied while the micro-channels from SkinPen are still open.
A supportive topical may be part of the care that follows your laser session.
Peptides are used to support firmness and smoothness in aging skin.
Either formula can fit into a broader, personalized plan for a healthier look.
Our certified advanced estheticians work with all skin types and tones.
Exosomes get bold claims online. Before you add one, you will know what it is meant to do and what the evidence currently shows.
Your results come mainly from the microneedling or laser session itself. The formula is there to support recovery and renewal.
Results vary from person to person, and we say so before you decide.
If your skin or goals do not call for it, we leave it out of your plan and tell you why.
We review your skin, history and routine, then explain whether a formula fits and what it pairs with.
Before microneedling or laser, you may be asked to pause retinoids and exfoliating products and avoid sun exposure.
Your skin is cleansed, then your provider performs the treatment in your plan, such as SkinPen microneedling.
The peptide or exosome formula goes onto the treated skin while it is most receptive.
Mild, sunburn-like redness is common for a day or two after microneedling. Skip makeup and actives as advised, and wear SPF daily.
Dr. Natalie Mesnier, MD, founded our medical spa. Today our team of Certified Advanced Estheticians and medical staff provides our skin treatments, including peptide and exosome add-ons.
Founder of our medspa, with a background in aesthetic medicine and certifications in PRP and neuromodulator applications.
★★★★★"Dr. Natalie Mesnier provided excellent skincare advice for my acne and menopausal skin and paired it perfectly with microneedling and laser treatments."
★★★★★"She checked on me daily while I was recovering, and I knew I was in good hands."
★★★★★"She maintains a forthright and direct approach when discussing treatment options."
The cost of a peptide or exosome add-on depends on the areas treated, the number of sessions and the treatment it is paired with. Your provider gives you an exact quote at your consultation, and our current menu is on the medspa pricing page.
We offer financing through Cherry, so you can spread the cost of a treatment plan into monthly payments.
Rejuv Facial Firming Peptides, from the Ortho-Rejuv skincare line, keeps peptides in your daily routine. Your provider tells you when to start it after treatment.
What patients ask before adding a formula to their treatment.
Neither is better across the board. Peptides are used to support firmness, smoothness and texture, while exosomes are used to support recovery and renewal after microneedling or laser. Your provider chooses based on your skin, your goals and the treatment in your plan.
For the right patient, an exosome formula supports a treatment you are already having. Research is still developing and results vary, so we explain what the evidence currently shows before you decide. If it does not make sense for your skin, we leave it out.
In our office, these formulas are applied right after a paired treatment such as SkinPen microneedling or laser, when the skin is most receptive. For daily use at home, your provider can add our Rejuv Facial Firming Peptides serum to your routine.
This page covers topical peptide and exosome formulas applied to the skin with an aesthetic treatment. Injected or oral peptide programs are a different category of care. If your goal is firmer, smoother skin, a topical formula paired with a skin treatment is what we discuss.
Recovery mainly follows the paired treatment. After microneedling, redness and sensitivity similar to a mild sunburn are common for a day or two. Applying the formula adds little or no recovery time on top of that.
Results depend on the paired treatment, your skin and the number of sessions in your plan, and they vary from person to person. Your provider tells you what you can realistically expect before treatment starts.
We will tell you whether peptides, exosomes or neither belong in your plan.
5050 NE Hoyt St #626, Portland, OR 97213
Venus is a Certified Advanced Esthetician, Certified Phlebotomy Technician, and pre-nursing student with a passion for medical aesthetics and patient-centered care. She is dedicated to helping clients achieve healthy, radiant skin through result-driven, customized treatments tailored to their unique needs. As a patient advocate at heart, Venus loves working with all skin types and creating long-term skincare plans that focus on both visible results and overall skin health.
Her favorite treatments include Aerolase, NeoGen, and microneedling, innovative treatment options that deliver real, transformative outcomes. Outside of the treatment room, Venus enjoys creating social media content, exploring new food spots, and spending time with friends and family
Certified Advanced Esthetician
Dr. Natalie Mesnier, the driving force behind Ortho-Rejuv Wellness and Aesthetics, stands at the forefront of aesthetic innovation. With a rich background in the aesthetic realm, she is notably skilled in anti-aging laser therapies, skin revitalization, and the meticulous use of injectables and fillers. Alongside her certifications in advanced aesthetic procedures, including PRP and neuromodulator applications, Dr. Mesnier’s mission is singular: to empower patients to experience and radiate their utmost beauty and confidence.
