Our medspa restores fullness to hollow temples, under-eyes and cheeks with dermal fillers, collagen-building biostimulators and PRF Ez-Gel, a filler made from your own blood.

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See Your PotentialSigns and Causes
The face holds its shape on fat pads, bone and collagen. As each one thins, the face looks hollow, flatter or tired, often before deep wrinkles appear.
A hollow at the sides of the forehead that makes the brow look heavier.
A groove between the lower lid and cheek that reads as tiredness.
Flatter cheekbones and less lift through the midface.
Deeper folds from nose to mouth as the cheek above loses support.
Thinner lips with a less defined border.
A softer jaw edge and early jowls.
Book when hollows make you look tired despite rest, when makeup settles into new folds, or after significant weight loss. Sudden volume loss on one side of the face needs a medical evaluation before any cosmetic treatment.
Treatment Options
Lost volume is best replaced directly. Dermal fillers are the most common way to do that, and they lead most volume plans at our medspa.
Biostimulators, PRF Ez-Gel and NeoGen are options for patients who want a gradual or more natural approach. Our providers recommend the right mix for each area at your consultation.
Injectable fillers restore shape to hollow temples, under-eyes, cheeks, smile lines, lips and the jawline, with a visible result right away.
Collagen boosters prompt your skin to build its own collagen, so volume and firmness return gradually over the following months.
A gel made entirely from your own blood. A small sample is spun and the plasma is heated and cooled into a gel, then blended with your platelet-rich fibrin and injected where volume was lost. Your body gradually absorbs it, so results are kept with repeat sessions.
NeoGen is not a filler, but it prompts your skin to build new collagen, which firms and supports the face from within. That can reduce how much injectable product you need, so it suits patients who want no injections or as few as possible. About the NeoGen Lift
Combine It With
Restoring shape and improving the skin over it are separate jobs. Once volume is restored, these in-house treatments can improve the quality of the skin that covers it.
Your own platelets
Growth factors from your own blood support renewal in thinning, aging skin.
Pairs naturally with fillers or PRF Ez-Gel
Collagen induction
The FDA-approved SkinPen creates micro-channels that prompt new collagen, boosted with your own plasma.
About 30 to 60 minutes per session
Skin-quality add-on
An optional add-on for rough texture and sun-damaged skin. It does not add volume, but it can refine the skin once volume is restored.
A healing period planned with you
What to Expect
Your provider studies your face from the front and side, maps where volume has gone and reviews your health history.
You leave knowing which areas need volume, which treatment fits each one and the exact cost.
Fillers are placed in the planned areas. For PRF Ez-Gel, your blood is drawn and prepared into gel first. Biostimulator and skin sessions follow on their own schedule.
Filled areas look fuller right away, while collagen builds over the following weeks. We review results and plan repeat sessions.

Our Practice
Dr. Natalie Mesnier, MD · Founder
Dr. Natalie Mesnier founded our medspa and has a background in aesthetic medicine. She is skilled in injectables and fillers and holds certifications in advanced aesthetic procedures, including PRP and neuromodulator applications.
Today our medspa brings together a team of Certified Advanced Estheticians and medical staff who provide our volume and skin treatments, with every plan built around your proportions and natural expression.
Reviews
Cassidy and Dr Mesnier were so knowledgeable about possible treatments that would work best for me.Tonya Flaming · Consultation
She maintains a forthright and direct approach when discussing treatment options.Chae Journette · Google review
Cost and Location
Cost depends on how many areas need volume, which treatment each area needs and which skin treatments you add. Filler sessions and collagen series are priced separately.
You receive an exact quote at your complimentary consultation, and monthly payment plans are available through Cherry.
We are in the Providence Plaza building at 5050 NE Hoyt St #626, Portland, OR 97213, across the street from Providence Hospital.
FAQ
Lost volume is replaced most directly with dermal fillers. Biostimulators rebuild collagen gradually, and PRF Ez-Gel is a filler made from your own blood. The skin over it can be improved with PRP or PRF facial rejuvenation, SkinPen microneedling or NeoGen as an add-on.
PRF Ez-Gel is made from your own plasma and platelets, so it contains no manufactured filler material. Your body gradually absorbs it, which is why many patients plan repeat sessions. Your provider explains which areas suit it and how long results are expected to last for you.
No. Jeuveau and Daxxify relax the muscles that crease the skin, but they do not add volume. Hollows from lost fat and bone need a filler. A relaxer can still be part of the same plan when expression lines are also a concern.
Fat leaves the face along with the rest of the body, so rapid weight loss can leave the cheeks and temples sunken and the skin looser. This is common with GLP-1 weight-loss medications. A plan for weight-related volume loss usually combines a filler with a skin-firming treatment.
Cost depends on how many areas need volume, which treatment each needs and which skin treatments are added. You receive an exact quote at your complimentary consultation, before any treatment. Monthly payment plans are available through Cherry.
Areas treated with dermal fillers or PRF Ez-Gel look fuller right away. Biostimulators and collagen treatments such as microneedling work more gradually, over the following weeks and months. We review your progress at a follow-up visit.
Complimentary Consultation
Leave knowing which areas have thinned, what will restore them and what your plan will cost.
5050 NE Hoyt St #626, Portland, OR 97213

Venus is a Certified Advanced Esthetician, Certified Phlebotomy Technician, and pre-nursing student with a passion for medical aesthetics and patient-centered care. She is dedicated to helping clients achieve healthy, radiant skin through result-driven, customized treatments tailored to their unique needs. As a patient advocate at heart, Venus loves working with all skin types and creating long-term skincare plans that focus on both visible results and overall skin health.
Her favorite treatments include Aerolase, NeoGen, and microneedling, innovative treatment options that deliver real, transformative outcomes. Outside of the treatment room, Venus enjoys creating social media content, exploring new food spots, and spending time with friends and family

Certified Advanced Esthetician




Dr. Natalie Mesnier, the driving force behind Ortho-Rejuv Wellness and Aesthetics, stands at the forefront of aesthetic innovation. With a rich background in the aesthetic realm, she is notably skilled in anti-aging laser therapies, skin revitalization, and the meticulous use of injectables and fillers. Alongside her certifications in advanced aesthetic procedures, including PRP and neuromodulator applications, Dr. Mesnier’s mission is singular: to empower patients to experience and radiate their utmost beauty and confidence.